Anti-Human CD274 Recombinant Antibody (TAB-417CQ)
CAT#: TAB-417CQ
Recombinant monoclonal antibody to CD274. This antibody is a human IgG1 monoclonal antibody that targets and binds to PD-L1, a protein that is often overexpressed on the surface of cancer cells and immune cells in the tumor microenvironment.









Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1, κ
- Specificity
- Human CD274
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, Inhib, FuncS
- Conjugate
- Unconjugated
- Related Disease
- Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The CD274 antibody has been reported in applications of ELISA, IHC, FC, IP, IF, Inhib, FuncS.
Target
Customer Review
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12.Sep,23

21.Oct,22

17.May,21
Q&As
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Is the anti-Durvalumab therapeutic antibody suitable for use in Western blotting?
A: Yes, the anti-Durvalumab therapeutic antibody (TAB-417CQ) is suitable for use in Western blotting. It provides specific binding to Durvalumab, allowing for reliable detection in Western blot assays.
-
What are the storage recommendations for the anti-Durvalumab therapeutic antibody?
A: The recommended storage condition for the anti-Durvalumab therapeutic antibody (TAB-417CQ) is at -20°C or lower. For short-term storage, it can be kept at 2-8°C. To ensure stability, avoid repeated freeze-thaw cycles.
-
Can the anti-Durvalumab therapeutic antibody be used in immunoprecipitation assays?
A: Yes, the anti-Durvalumab therapeutic antibody (TAB-417CQ) can be used in immunoprecipitation assays. It provides specific binding to Durvalumab, enabling the successful precipitation of the target protein from complex mixtures.
-
Is the anti-Durvalumab therapeutic antibody effective in ELISA applications?
A: Yes, the anti-Durvalumab therapeutic antibody (TAB-417CQ) is effective in ELISA applications. It has been validated for use in such assays and provides reliable detection of Durvalumab.
-
What is the optimal dilution for using the anti-Durvalumab therapeutic antibody in immunofluorescence?
A: The optimal dilution for using the anti-Durvalumab therapeutic antibody (TAB-417CQ) in immunofluorescence is typically 1:100 to 1:500. It is advisable to perform a dilution series to determine the best working concentration for your specific experimental conditions.
View the frequently asked questions answered by Creative Biolabs Support.
Citations
-
Li, Yumei, et al. "A novel multifunctional anti-PD-L1-CD16a-IL15 induces potent cancer cell killing in PD-L1-positive tumour cells." Translational Oncology 21 (2022): 101424. https://doi.org/10.1016/j.tranon.2022.101424This study explores the creation and efficacy of a novel multifunctional antibody, anti-PD-L1-CD16a-IL15, designed to target and kill PD-L1-overexpressing tumor cells. The researchers utilized recombinant human PD-L1-immunized llamas to develop anti-PD-L1 single-domain antibodies, which were then linked with anti-CD16a single-domain antibodies and the IL-15/IL-15Ra complex. This fusion protein, expressed and purified from HEK-293F cells, demonstrated significant in vitro and in vivo antitumor activity. It recruits T cells and activates NK cells to specifically target and kill PD-L1-positive tumor cells, showing enhanced efficacy over other antibody constructs in both cell cultures and xenograft models.
Creative Biolabs played a crucial role in this research by supplying several key reagents. Specifically, they provided the durvalumab antibody (Cat#: TAB-417CQ) used for comparison in cell proliferation assays and cytotoxicity studies. The comprehensive testing of anti-PD-L1-CD16a-IL15, including binding affinity, immune cell recruitment, and tumor inhibition, was facilitated by these high-quality reagents from Creative Biolabs. The products contributed to the study's ability to demonstrate the potential of anti-PD-L1-CD16a-IL15 as a potent cancer immunotherapy.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-417CQ, RRID: AB_3111930)
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Biosimilar Overview
Please refer to Durvalumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Durvalumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Cd274"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-298 | Human Anti-CD274 Recombinant Antibody (clone CBLC-006); scFv Fragment | WB, ELISA, FuncS | Human scFv |
HPAB-0197-YC-S(P) | Rabbit Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0197-YC-S(P)) | ELISA, FC | Rabbit scFv |
HPAB-0198-YC-S(P) | Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0198-YC-S(P)) | ELISA, FC, Block | Mouse scFv |
HPAB-0199-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0199-YC-S(P)) | ELISA, FC, Block | Mouse scFv |
HPAB-0200-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0200-YC-S(P)) | ELISA, FC, Block | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0262CL | Mouse Anti-CD274 Recombinant Antibody (TAB-0262CL) | ELISA, WB, SPR, ADCC, CDC, FuncS | Mouse IgG |
TAB-0262CL-S(P) | Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0262CL-S(P)) | ELISA, WB, SPR, FuncS | Mouse scFv |
TAB-0262CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0262CL-F(E)) | ELISA, WB, SPR, FuncS | Mouse Fab |
TAB-1009CL-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1009CL-F(E)) | WB, IHC | Mouse Fab |
TAB-1010CL-F(E) | Anti-Human CD274 Recombinant Antibody Fab Fragment | FC |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0995CL | Human Anti-CD274 Recombinant Antibody (TAB-0995CL) | ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
TAB-0995CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P)) | ELISA, FC | Human scFv |
TAB-0995CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0263CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0263CL-S(P)) | ELISA, WB, SPR, FuncS | Humanized scFv |
TAB-0264CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0264CL-S(P)) | ELISA, WB, SPR, Inhib, FuncS | Humanized scFv |
TAB-0265CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0265CL-S(P)) | ELISA, WB, SPR, FuncS | Humanized scFv |
TAB-0996CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0996CL-S(P)) | ELISA, FC | Human scFv |
TAB-418CQ | Anti-Human CD274 Recombinant Antibody (TAB-418CQ) | ELISA, IHC, FC, IP, IF, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0998CL | Anti-Human CD274 Recombinant Antibody (BII61-62) | ELISA, FuncS | Human antibody |
TAB-0999CL | Anti-Human CD274 Recombinant Antibody (B50-6) | FuncS | Human antibody |
TAB-1000CL | Human Anti-CD274 Recombinant Antibody (TAB-1000CL) | Inhib, FC | Human IgG1 |
TAB-1001CL | Human Anti-CD274 Recombinant Antibody (TAB-1001CL) | ADCC, Block, FuncS | Human IgG |
TAB-0998CL-F(E) | Anti-Human CD274 Recombinant Antibody Fab Fragment (BII61-62) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2354MZ | Mouse Anti-CD274 Recombinant Antibody (clone NJI3) | FC | Mouse IgG1 |
HPAB-0196-YC | Human Anti-CD274 Recombinant Antibody (HPAB-0196-YC) | FC | Human IgG |
HPAB-0197-YC | Rabbit Anti-CD274 Recombinant Antibody (HPAB-0197-YC) | ELISA, FC | Rabbit IgG |
HPAB-0198-YC | Mouse Anti-CD274 Recombinant Antibody (HPAB-0198-YC) | ELISA, FC, Block | Mouse IgG |
HPAB-0199-YC | Human Anti-CD274 Recombinant Antibody (HPAB-0199-YC) | ELISA, FC, Block | Chimeric (mouse/human) IgG4, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-324CQ | Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6) | IHC-P, FC, Neut, ICC | Mouse IgG2b, κ |
NEUT-325CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-206) | Neut | Human IgG1, κ |
NEUT-326CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-207) | ELISA, Neut | Human IgG1, κ |
NEUT-327CQ | Mouse Anti-CD274 Recombinant Antibody (clone MIH1) | FC, FuncS, Neut, IHC, IF | Mouse IgG1, κ |
NEUT-330CQ | Rat Anti-CD274 Recombinant Antibody (clone MIH5) | FC, FuncS, Neut, IHC-Fr, WB | Rat IgG2a, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-328CQ | Rat Anti-CD274 Recombinant Antibody (VMC171) | Block, FC | Rat IgG2 |
NEUT-329CQ | Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2) | FC, IF, Block | Rat IgG2b, κ |
NEUT-331CQ | Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1) | ELISA, Block | Mouse IgG1, λ |
NEUT-332CQ | Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009) | Block | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0548 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB) | ELISA | Rabbit IgG |
MOR-4049 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS) | ELISA | Rabbit IgG |
MOR-4050 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS) | ICC, IF, FC | Rabbit IgG |
MOR-4051 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS) | FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0193-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0193-YC-F(E)) | ELISA | Humanized Fab |
HPAB-0194-YC-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0194-YC-F(E)) | ELISA | Mouse Fab |
HPAB-0195-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0195-YC-F(E)) | SPR | Humanized Fab |
HPAB-0196-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0196-YC-F(E)) | FC | Human Fab |
HPAB-0197-YC-F(E) | Rabbit Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0197-YC-F(E)) | ELISA, FC | Rabbit Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-417CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
AFC-TAB-418CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NBD-0065-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH) | ELISA | Camelid VHH |
NBD-0066-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH) | ELISA, Inihb | Camelid VHH |
NBD-0067-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0067-YJ-VHH) | ELISA, FC | Camelid VHH |
NBD-0068-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0068-YJ-VHH) | ELISA, FC | Camelid VHH |
NBD-0069-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0069-YJ-VHH) | ELISA, FC | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC110 | Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC | Antibody hexamer |
VS-0924-YC111 | Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC, Inhib | Antibody hexamer |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-1024-XY375 | Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY32 | CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-FY65 | Human Anti-CD274 (clone MI4736) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC608 | Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608) | Block, ELISA, FC, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY1152 | Anti-CD274 Immunohistochemistry Kit | IHC | |
VS-0525-XY1153 | Anti-Mouse CD274 Immunohistochemistry Kit | IHC | |
VS-0525-XY1154 | Anti-Human CD274 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-YC202 | Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv | ELISA, IHC, FC, IP, IF | Tandem scFv |
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